… GWAS often require very large sample sizes to identify reproducible genome-wide significant
associations and the desired sample size can be determined using power calculations in …

… Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

… the genome-wide association … studies that are designed and executed with low statistical
power and inadequate quality control. Here, in the context of genome-wide association studies …

… In this chapter we focus on the genome-wide association study or GWAS, a novel approach
that has revolutionized the study of genetics of complex disorders. This approach examines …

… genome-wide studies will further improve our understanding of the disease process, risks,
and response to therapy. The impact of these studies … large majority of genome-wide findings. …

Genome-wide association studies involving hundreds of thousands of SNPs in thousands of
cases and controls are now underway. The first of many analytical challenges in these …

… Meta-analysis of genome-wide association studies has contributed to the discovery of most
… Meta-analysis of genome-wide association studies (GWASs) has become a popular method …

… genome-wide association (GWA) studies. An example is shown to illustrate that many
genes in a susceptibility pathway may show evidence of association, although not genome-wide …

… The genetic risk factors identified by genome-wide association studies are likely to be
associated with moderate risks (as is the case with most known environmental risk factors), rather …

… that can be used to carry out genome-wide association studies (GWASs). The availability of
… the discovery of new associations that have been replicated in multiple studies. However, it …